196 research outputs found

    In-process tool wear prediction system based on machine learning techniques and force analysis

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    This paper presents an in-process tool wear prediction system, which uses a force sensor to monitor the progression of the tool flank wear and machine learning (ML), more specifically, a Convolutional Neural Network (CNN) as a method to predict tool wear. The proposed methodology is experimentally illustrated using milling as a test process. The experiments are conducted using dry machining with a non-coated ball endmill and a stainless steel workpiece. The measurement of the flank wear is carried on in-situ utilising a digital microscope. The ML model predictions are based on an experience database which contains all the data of the precedent experiments. The proposed in-process tool wear prediction system will be reinforced later by an adaptive control (AC) system that will communicate continuously with the ML model to seek the best adjustment of feed rate and spindle speed that allows the optimization of the flank wear and extend the tool life. The AC model decisions are based on the prediction delivered by the ML model and on the information feedback provided from the force sensor, which captures the change in the cutting forces as a function of the progression of the flank wear. In this work, only the ML model component for the estimation of tool wear based on CNNs is demonstrated. The proposed methodology has shown an estimated accuracy of 90%. Additional experiments will be performed to confirm the repetitiveness of the results and also extend the measurement range to improve accuracy of the measurement system

    Experiencias interdisciplinarias en alimentación y daños a la salud en las fronteras sur y norte de México

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    Los problemas de salud y alimentación en diferentes contextos como las fronteras sur y norte de México exige de trabajo interdisciplinar, con lenguajes y bases comunes para los grupos académicos. El objetivo de esta ponencia es reflexionar sobre la experiencia del grupo Seminario de “Alimentación y Daños a la Salud” (ADAS), el cual busca consolidar una propuesta de colaboración interinstitucional para el abordaje interdisciplinario de los problemas de salud relacionados con la alimentación y vulnerabilidad social en la frontera sur y norte de México.Facultad de Humanidades y Ciencias de la Educació

    Experiencias interdisciplinarias en alimentación y daños a la salud en las fronteras sur y norte de México

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    Los problemas de salud y alimentación en diferentes contextos como las fronteras sur y norte de México exige de trabajo interdisciplinar, con lenguajes y bases comunes para los grupos académicos. El objetivo de esta ponencia es reflexionar sobre la experiencia del grupo Seminario de “Alimentación y Daños a la Salud” (ADAS), el cual busca consolidar una propuesta de colaboración interinstitucional para el abordaje interdisciplinario de los problemas de salud relacionados con la alimentación y vulnerabilidad social en la frontera sur y norte de México.Facultad de Humanidades y Ciencias de la Educació

    Obesity Indexes and Total Mortality among Elderly Subjects at High Cardiovascular Risk: The PREDIMED Study

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    BackgroundDifferent indexes of regional adiposity have been proposed for identifying persons at higher risk of death. Studies specifically assessing these indexes in large cohorts are scarce. It would also be interesting to know whether a dietary intervention may counterbalance the adverse effects of adiposity on mortality.MethodsWe assessed the association of four different anthropometric indexes (waist-to-height ratio (WHtR), waist circumference (WC), body mass index (BMI) and height) with all-cause mortality in 7447 participants at high cardiovascular risk from the PREDIMED trial. Forty three percent of them were men (55 to 80 years) and 57% were women (60 to 80 years). All of them were initially free of cardiovascular disease. The recruitment took place in 11 recruiting centers between 2003 and 2009.ResultsAfter adjusting for age, sex, smoking, diabetes, hypertension, intervention group, family history of coronary heart disease, and leisure-time physical activity, WC and WHtR were found to be directly associated with a higher mortality after 4.8 years median follow-up. The multivariable-adjusted HRs for mortality of WHtR (cut-off points: 0.60, 0.65, 0.70) were 1.02 (0.78–1.34), 1.30 (0.97–1.75) and 1.55 (1.06–2.26). When we used WC (cut-off points: 100, 105 and 110 cm), the multivariable adjusted Hazard Ratios (HRs) for mortality were 1.18 (0.88–1.59), 1.02 (0.74–1.41) and 1.57 (1.19–2.08). In all analyses, BMI exhibited weaker associations with mortality than WC or WHtR. The direct association between WHtR and overall mortality was consistent within each of the three intervention arms of the trial.ConclusionsOur study adds further support to a stronger association of abdominal obesity than BMI with total mortality among elderly subjects at high risk of cardiovascular disease. We did not find evidence to support that the PREDIMED intervention was able to counterbalance the harmful effects of increased adiposity on total mortality.Trial RegistrationControlled-Trials.com ISRCTN3573963

    GABA-A Channel Subunit Expression in Human Glioma Correlates with Tumor Histology and Clinical Outcome

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    GABA (γ-aminobutyric acid) is the main inhibitory neurotransmitter in the CNS and is present in high concentrations in presynaptic terminals of neuronal cells. More recently, GABA has been ascribed a more widespread role in the control of cell proliferation during development where low concentrations of extrasynaptic GABA induce a tonic activation of GABA receptors. The GABA-A receptor consists of a ligand-gated chloride channel, formed by five subunits that are selected from 19 different subunit isoforms. The functional and pharmacological properties of the GABA-A channels are dictated by their subunit composition. Here we used qRT-PCR to compare mRNA levels of all 19 GABA-A channel subunits in samples of human glioma (n = 29) and peri-tumoral tissue (n = 5). All subunits except the ρ1 and ρ3 subunit were consistently detected. Lowest mRNA levels were found in glioblastoma compared to gliomas of lower malignancy, except for the θ subunit. The expression and cellular distribution of the α1, γ1, ρ2 and θ subunit proteins was investigated by immunohistochemistry on tissue microarrays containing 87 gliomas grade II. We found a strong co-expression of ρ2 and θ subunits in both astrocytomas (r = 0.86, p<0.0001) and oligodendroglial tumors (r = 0.66, p<0.0001). Kaplan-Meier analysis and Cox proportional hazards modeling to estimate the impact of GABA-A channel subunit expression on survival identified the ρ2 subunit (p = 0.043) but not the θ subunit (p = 0.64) as an independent predictor of improved survival in astrocytomas, together with established prognostic factors. Our data give support for the presence of distinct GABA-A channel subtypes in gliomas and provide the first link between specific composition of the A-channel and patient survival

    Corporate Social Responsibility Strategies of Spanish Listed Firms and Controlling Shareholders’ Representatives

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    This article aims at analyzing how controlling shareholders’ representatives on boards affect corporate social responsibility (CSR) strategies (disclosing CSR matters) in Spain, a context characterized by high ownership concentration, one-tier boards, little board independence, weak legal protection for investors, and the presence of large shareholders, especially institutional shareholders. Furthermore, among controlling shareholders’ representatives, we can distinguish between those appointed by insurance companies and banks and those appointed by mutual funds, investment funds, and pension funds. The effect of these categories of directors on CSR strategies is, therefore, also analyzed. Our findings suggest that controlling shareholders’ representatives have a positive effect on CSR strategies, as do directors appointed by investment funds, pension funds, and mutual funds, while directors appointed by banks and insurance companies have no impact on CSR strategies. This analysis offers new insights into the role played by certain types of directors on CSR strategies
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